Cancer risk estimates for family members of a population-based family registry for breast and ovarian cancer

Ziogas, A Gildea, M Cohen, P Bringman, D Taylor, TH Seminara, D Barker, D Casey, G Haile, R Liao, SY Thomas, D Noble, B Kurosaki, T Anton-Culver, H

A. Ziogas et al., Cancer risk estimates for family members of a population-based family registry for breast and ovarian cancer, CANC EPID B, 9(1), 2000, pp. 103-111

45

INGLESE

Article

Oncology,"Onconogenesis & Cancer Research

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

1055-9965 → ACNP

9

1

2000

103 - 111

ISI

1055-9965(200001)9:1<103:CREFFM>2.0.ZU;2-T

Population-based breast and ovarian cancer family registries can facilitate studies to evaluate genetic and environmental factors in the etiology of t hese malignancies. The purpose of this study is to describe what is, as far as we know, the first population-based breast and ovarian cancer family re gistry and to estimate breast and ovarian cancer risk in relatives of breas t and ovarian cancer probands, Population-based consecutive incident cases of breast and ovarian cancer were invited to participate in the University of California, Irvine breast and ovarian family registry. In this study, we report data on 1567 breast cancer and 328 ovarian cancer probands, The ope rational components of this family registry include enrollment of probands, family history interviewing, confidentiality, pathology, verification and review, biospecimen bank, statistical/genetic analysis, and special studies on positional cloning of known genes. All of the components are tracked th rough the University of California, Irvine Genetic Research Information Sys tem. In non-Hispanic-white breast cancer probands, relative risk (RR) of br east cancer in mothers and sisters is significantly elevated [RR = 1.7 and 95% confidence interval (CI) = 1.4-2.0 and RR = 2.8 and 95% CI = 2.3-3.3, r espectively]. In families of ovarian cancer probands, mothers are at increa sed risk of ovarian cancer (RR = 4.6; 95% CI, 2.1-8.7), RR of breast cancer in mothers of Hispanic breast cancer probands is significantly elevated (R R = 4.9; 95% CI, 2.6-8.5). No elevation of breast or ovarian cancer risk wa s observed among relatives of Asian probands, In general, there is a decrea se in RR among mothers and sisters with increase in age of onset of proband s, In second-degree relatives and first cousins, the breast cancer hazards ratios increase with increase in the number of affected first-degree relati ves and decrease with increase in age at onset of the proband.