The synthesis and biological activity of a series of new 1 beta-methylcarba
penems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2
side chain are described. Most compounds exhibited potent and well-balanced
antibacterial activity as well as high stability to DHP-1 comparable to th
at of meropenem. 1e and 1c showed the best combination of antibacterial act
ivity and stability to DHP-1, respectively. (C) 2000 Elsevier Science Ltd.
All rights reserved.