Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety

Citation
Yk. Kang et al., Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety, BIOORG MED, 10(2), 2000, pp. 95-99
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
95 - 99
Database
ISI
SICI code
0960-894X(20000117)10:2<95:SAAAON>2.0.ZU;2-L
Abstract
The synthesis and biological activity of a series of new 1 beta-methylcarba penems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-1 comparable to th at of meropenem. 1e and 1c showed the best combination of antibacterial act ivity and stability to DHP-1, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.