Cyclophosphamide and carboplatin and selective consolidation in advanced seminoma

Citation
Rj. Amato et al., Cyclophosphamide and carboplatin and selective consolidation in advanced seminoma, CLIN CANC R, 6(1), 2000, pp. 72-77
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
CLINICAL CANCER RESEARCH
ISSN journal
1078-0432 → ACNP
Volume
6
Issue
1
Year of publication
2000
Pages
72 - 77
Database
ISI
SICI code
1078-0432(200001)6:1<72:CACASC>2.0.ZU;2-2
Abstract
This prospective Phase II study assesses the clinical efficacy and complica tions of a treatment regimen of combination chemotherapy with cyclophospham ide and carboplatin and selective consolidation in advanced seminoma, Of 46 patients who entered the study between December 1992 and October 1998, 46 were evaluable. Thirty-two achieved a complete remission (70%; 95% confiden ce interval, 56-83%) after chemotherapy alone. Fourteen achieved a complete remission (30%; 95% confidence interval, 18-46%) after chemotherapy plus c onsolidation. Forty-three of the 46 patients (93%; 95% confidence interval, 82-97%) remained in remission after a median follow-up period of 27.4 mont hs, No patient experienced nephrotoxic, neurotoxic, or ototoxic effects or hemorrhagic cystitis, No patient had neutropenic fever requiring hospitaliz ation. Thirteen % required platelet transfusions, and 9% required transfusi ons of packed RBCs, For patients with advanced seminoma, treatment with cyc lophosphamide and carboplatin and selective consolidation is safe and effec tive.