A scale-up strategy into 200 l pilot-scale for the production of the antibi
otic gallidermin by Staphylococcus gallinarum Tu 3928 was developed. Large-
scale fermentations were simulated by consecutive liquid cultures of smalle
r scale. Afterwards, optimised cultivation conditions were transferred to p
ilot-scale. Best results were achieved by addition of Maltose during the la
te production phase leading to a final concentration of 330 mg gallidermin
per litre. Compared to the concentrations found in a non-pulsed pilot-scale
fermentations this is an increase of 20-30%.