Stromal thrombospondin-1 expression is correlated with progression of esophageal squamous cell carcinomas

Citation
G. Oshiba et al., Stromal thrombospondin-1 expression is correlated with progression of esophageal squamous cell carcinomas, ANTICANC R, 19(5C), 1999, pp. 4375-4378
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTICANCER RESEARCH
ISSN journal
0250-7005 → ACNP
Volume
19
Issue
5C
Year of publication
1999
Pages
4375 - 4378
Database
ISI
SICI code
0250-7005(199909/10)19:5C<4375:STEICW>2.0.ZU;2-S
Abstract
Thrombospondin-1 (TSP1) is an extracellular matrix glycoproteins that affec ting cell adhesion motility and growth. Based on its effects on tumors, TSP 1 is thought to be a potential regulator of tumor growth and metastasis. In this study, we clarified TSP1 immunoreactivity in human esophageal squamou s cell carcinoma and its clinicopathological significance. TSP1 immunoreact ivity was detected mainly in the cancer stroma and was observed infrequentl y in cancer cells. According to the TNM classification 70.6% (12/17) of the T3 esophageal cancels were TSP1-positive, while only 26.9% (7/26) of the T is and TI cancers showed TSP1 expression. Lymph node metastasis and venous involvement was frequently found in the TSP1-positive cases (71.4% and 80.0 %, respectively) of esophageal squamous cell carcinoma (p < 0.001). This ob servation suggested that TSP1 expression plays an important role in cancer cell growth and metastasis of human esophageal squamous cell carcinomas, an d that stromal TSP1 immunoreactivity is a good predictor of venous involvem ent and lymph node metastasis.