EFFECTS OF ENALAPRIL ON LEFT-VENTRICULAR FUNCTION AND EXERCISE PERFORMANCE AFTER A FIRST ACUTE MYOCARDIAL-INFARCTION

Citation
Fs. Garri et al., EFFECTS OF ENALAPRIL ON LEFT-VENTRICULAR FUNCTION AND EXERCISE PERFORMANCE AFTER A FIRST ACUTE MYOCARDIAL-INFARCTION, International journal of cardiology, 59(3), 1997, pp. 257-265
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiac & Cardiovascular System
ISSN journal
0167-5273
Volume
59
Issue
3
Year of publication
1997
Pages
257 - 265
Database
ISI
SICI code
0167-5273(1997)59:3<257:EOEOLF>2.0.ZU;2-H
Abstract
Aims: To study the effects of early use of enalapril on left ventricul ar function and exercise capacity after a first acute myocardial infar ction, 356 patients without overt signs of congestive heart failure we re randomly allocated to receive placebo or enalapril between days 7 a nd 14 after a first myocardial infarction. The study was conducted dou ble-blind in 40 hospitals throughout Spain. Methods and results: At ba seline and after 26 weeks of follow-up exercise stress tests, Doppler- echocardiograms and isotopic ventriculography were performed in study participants. At the end of follow-up, patients in the enalapril group had lower end-systolic volume compared to those in the placebo group (55 vs. 62 ml, P=0.05). No difference in exercise capacity was evident between both groups. Conclusion: The present study shows that enalapr il therapy administered between 7 and 14 days after a first acute myoc ardial infarction decreases end-systolic volume and may inhibit the re modeling process of the left ventricle. (C) 1997 Elsevier Science Irel and Ltd.