Pharmacokinetics and pharmacodynamics of moist snuff in humans

Citation
Rv. Fant et al., Pharmacokinetics and pharmacodynamics of moist snuff in humans, TOB CONTROL, 8(4), 1999, pp. 387-392
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public Health & Health Care Science","Envirnomentale Medicine & Public Health
Journal title
TOBACCO CONTROL
ISSN journal
0964-4563 → ACNP
Volume
8
Issue
4
Year of publication
1999
Pages
387 - 392
Database
ISI
SICI code
0964-4563(199924)8:4<387:PAPOMS>2.0.ZU;2-A
Abstract
Objective-To examine the effects of four brands of commercially available m oist snuff and non-tobacco mint "snuff" on plasma nicotine concentration, h eart rate, blood pressure, and subjective measures. Intervention-Four brands of moist snuff and a non-tobacco mint snuff were t ested. Subjects reported to the laboratory for five experimental sessions. After baseline measurement of dependent variables, each subject placed 2 g of one of the brands of snuff (or one Skoal Bandits pouch) between the chee k and gum for 30 minutes. The subjects remained in the experimental laborat ory for an additional 60 minutes. Subjects-Ten volunteers who were daily users of smokeless tobacco. Main outcome measures-Plasma nicotine concentration, cardiovascular effects , and subjective effects. Results-Large amounts of nicotine were delivered rapidly to the bloodstream . The amount of nicotine absorbed and the rate of absorption were related t o the pH of the snuff product in aqueous suspension. Cardiovascular and sub jective effects were related to me amount of nicotine absorbed. Conclusions-Snuff products are capable of rapidly delivering high doses of nicotine, which can lead to dependence. Long-term use of snuff can lead to a number of adverse health effects including oral cancers, cardiovascular d iseases, and gingival diseases. For these reasons, it is important that the public health community considers oral snuff use as a burden on public hea lth in the same way that cigarette smoking is recognised.