Enhancement of conditioned place preference response to cocaine in rats following subchronic administration of 3,4-methylenedioxymethamphetamine (MDMA)

Citation
B. Horan et al., Enhancement of conditioned place preference response to cocaine in rats following subchronic administration of 3,4-methylenedioxymethamphetamine (MDMA), SYNAPSE, 35(2), 2000, pp. 160-162
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
SYNAPSE
ISSN journal
0887-4476 → ACNP
Volume
35
Issue
2
Year of publication
2000
Pages
160 - 162
Database
ISI
SICI code
0887-4476(200002)35:2<160:EOCPPR>2.0.ZU;2-H
Abstract
In this study, we measured conditioned place preference (CPP) responses to cocaine following subchronic administration of the recreationally abused dr ug (+/-)-3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in male Spragu e-Dawley rats. Animals were given either vehicle (1 ml/kg of distilled wate r, s.c.) or MDMA (20 mg/kg, s.c.) twice a day for 4 consecutive days. Two w eeks later, CPP responses to cocaine (5, 10, or 20 mg/kg, i.p.) were measur ed. The MDMA-treated animals showed a significantly greater CPP response to cocaine than the vehicle-treated animals. Since conditioned place preferen ce is believed to be a measure of appetitive behavior, these results sugges t that MDMA abuse could lead to an increased vulnerability to the rewarding actions of cocaine and, hence, to increased vulnerability to cocaine addic tion and dependence. (C) 2000 Wiley-Liss, Inc.