Synthesis, characterization and antifungal activity of group 12 metal complexes of 2-acetylpyridine-N-4-ethylthiosemicarbazone (H4EL) and 2-acetylpyridine-N-oxide-N-4-ethylthiosemicarbazone (H4ELO)

Citation
E. Bermejo et al., Synthesis, characterization and antifungal activity of group 12 metal complexes of 2-acetylpyridine-N-4-ethylthiosemicarbazone (H4EL) and 2-acetylpyridine-N-oxide-N-4-ethylthiosemicarbazone (H4ELO), POLYHEDRON, 18(27), 1999, pp. 3695-3702
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
POLYHEDRON
ISSN journal
0277-5387 → ACNP
Volume
18
Issue
27
Year of publication
1999
Pages
3695 - 3702
Database
ISI
SICI code
0277-5387(1999)18:27<3695:SCAAAO>2.0.ZU;2-J
Abstract
Reaction of group 12 metal halides in ethanol with the thiosemicarbazones 2 -acetyrpyridine-N-4-ethylthiosemicarbazone (H4EL) and 2-acetylpyridine-N-ox ide-N-4-ethylthiosemicarbazone (H4ELO) produced the compounds [M(H4EL)X-2] and [M(H4ELO)X-2] [M=Zn(II), Cd(II) or Hg(II), X=Cl, Br or I]. The ligands and complexes were characterized by elemental analysis and by IR and NMR (H -1, C-13, Cd-113, Hg-199) Spectroscopy, and the structures of H4ELO . H2O a nd the complexes [Cd(H4EL)I-2]. 2DMSO, [Hg(H4EL)Br-2]-DMSO, [Zn(H4ELO)Cl-2] and [Zn(H4ELO)Br-2] were determined by X-ray diffraction. The metal center s in the complexes have coordination number five, H4EL and H4ELO behaving a s neutral NNS- and ONS-tridentate ligands, respectively. The coordination p olyhedra are close to tetragonal pyramids, the degree of distortion towards trigonal bipyramids was estimated by tau calculation. Against the pathogen ic fungi Aspergillus niger and Paecilomyces variotii, the mercury complexes of H4ELO had activities that at some doses exceeded that of nystatin. (C) 1999 Elsevier Science Ltd. All rights reserved.