Protein-losing enteropathy caused by mesenteric venous thrombosis with protein C deficiency

Citation
I. Matsushita et al., Protein-losing enteropathy caused by mesenteric venous thrombosis with protein C deficiency, J CLIN GAST, 30(1), 2000, pp. 94-97
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
JOURNAL OF CLINICAL GASTROENTEROLOGY
ISSN journal
0192-0790 → ACNP
Volume
30
Issue
1
Year of publication
2000
Pages
94 - 97
Database
ISI
SICI code
0192-0790(200001)30:1<94:PECBMV>2.0.ZU;2-S
Abstract
A 63-year-old man presented with leg edema and hypoproteinemia. His alpha-1 antitrypsin clearance rate of 174 mL/day indicated the presence of protein -losing enteropathy (PLE). Computed tomographic scans demonstrated thickene d ileal wall and mesenteric edema. Angiography revealed occlusion in a peri pheral branch of the superior mesenteric vein. Furthermore, both the patien t and his son had low protein C levels. The patient was treated successfull y with partial resection of the ileum. Histologic examination of the resect ed ileum revealed multiple erosions and submucosal fibrosis with organized venous thrombi in the mesenteric veins. This is the first case report of PL E caused by mesenteric venous thrombosis, and our findings suggest that ser um protein was lost through erosion of the ileum caused by ischemia due to mesenteric venous thrombosis.