Treatment of fungal infections in surgical patients using conventional antifungals

Citation
Be. De Pauw et al., Treatment of fungal infections in surgical patients using conventional antifungals, J CHEMOTHER, 11(6), 1999, pp. 494-503
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology
Journal title
JOURNAL OF CHEMOTHERAPY
ISSN journal
1120-009X → ACNP
Volume
11
Issue
6
Year of publication
1999
Pages
494 - 503
Database
ISI
SICI code
1120-009X(199912)11:6<494:TOFIIS>2.0.ZU;2-I
Abstract
In surgical and intensive care units an alarming increase in the number of invasive fungal infections has been observed. This is partly due to tempora l transferral of patients from hemato-oncological units or transplant units and partly to the enhanced use of corticosteroids and other immunosuppress ants. Candida species have now become a common isolate in ill patients. Amp hotericin B with or without flucytosine constituted the standard therapy fo r candidosis but similar response rates with less toxicity may be obtained with Lipid and with fluconazole, Data on an improved outcome of candidemia if a central venous catheter is removed promptly are conflicting. Amphoteri cin B remains the standard therapy for other invasive mycoses; it is seldom possible to administer adequate doses and therefore the options and limita tions of the triazoles and liposomal preparations should be explored.