A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation

Citation
J. Li et al., A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation, J CELL BIOL, 147(7), 1999, pp. 1391-1397
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
JOURNAL OF CELL BIOLOGY
ISSN journal
0021-9525 → ACNP
Volume
147
Issue
7
Year of publication
1999
Pages
1391 - 1397
Database
ISI
SICI code
0021-9525(199912)147:7<1391:ANMB1I>2.0.ZU;2-3
Abstract
Myogenesis is regulated by cell adhesion receptors, including integrins of the beta 1 family. We report the identification of a novel muscle-specific beta 1 integrin binding protein (MIBP). MIBP binds to the membrane-proximal cytoplasmic region shared by beta 1A and beta 1D integrins, and the bindin g occurs in vivo as well as in vitro. Furthermore, we show that MIBP is abu ndantly expressed by C2C12 myogenic cells before fusion, and the expression of MIBP is dramatically downregulated during subsequent differentiation. F inally, we show that overexpression of MIBP in C2C12 cells resulted in a su ppression of fusion and terminal differentiation, suggesting that MIBP may play a key role in controlling the progression of muscle differentiation.