Cholangiocarcinoma in patients with primary sclerosing cholangitis: A multicenter case-control study

Citation
N. Chalasani et al., Cholangiocarcinoma in patients with primary sclerosing cholangitis: A multicenter case-control study, HEPATOLOGY, 31(1), 2000, pp. 7-11
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
HEPATOLOGY
ISSN journal
0270-9139 → ACNP
Volume
31
Issue
1
Year of publication
2000
Pages
7 - 11
Database
ISI
SICI code
0270-9139(200001)31:1<7:CIPWPS>2.0.ZU;2-K
Abstract
Patients with primary sclerosing cholangitis (PSC) have a significantly inc reased risk of developing cholangiocarcinoma (CCA), Risk factors for develo ping such a complication are not well defined, We conducted a multicenter, case-control study to determine the risk factors and possible predictors fo r CCA in patients with PSC, The demographic, clinical, and laboratory featu res of 26 PSC patients with CCA diagnosed over a 7-year period at eight aca demic centers were compared with 87 patients with PSC but no CCA (controls) , There was no statistically significant difference in demographics, smokin g, si,ans or symptoms or complications of PSC, indices of disease severity (Mayo Risk score or Child-Pugh score), frequency or duration or complicatio ns of inflammatory bowel disease (IBD), frequency of biliary surgery, or th erapeutic endoscopy between the two groups, Alcohol consumption was signifi cantly associated with CCA in patients with PSC (odds ratio: 2.95; 95% CI: 1.04-8.3), Serum carbohydrate antigen 19-9 (CA 19-9) was significantly high er in patients with CCA than those without (177 +/- 89 and 61 +/- 58 U/mL, respectively; P = .002), A serum CA 19-9 level > 100 U/mL had 75% sensitivi ty and 80% specificity in identifying PSC patients with CCA, In conclusion, alcohol consumption was a risk factor for having CCA in PSC patients, The indices of severity of liver disease were not associated with CCA in patien ts with PSC, Serum CA 19-9 appeared to have good ability to discriminate PS C patients with and without CCA.