Cancer chemoprevention: Progress and promise (Reprinted from Eur J Cancer,vol 35, pg 1755-1762, 1999)

Citation
Gj. Kelloff et al., Cancer chemoprevention: Progress and promise (Reprinted from Eur J Cancer,vol 35, pg 1755-1762, 1999), EUR J CANC, 35(14), 1999, pp. 2031-2038
Citations number
42
Language
INGLESE
art.tipo
Reprint
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
EUROPEAN JOURNAL OF CANCER
ISSN journal
0959-8049 → ACNP
Volume
35
Issue
14
Year of publication
1999
Pages
2031 - 2038
Database
ISI
SICI code
0959-8049(199912)35:14<2031:CCPAP(>2.0.ZU;2-G
Abstract
Cancer chemoprevention is the use of agents to inhibit, delay or reverse ca rcinogenesis. The focus of chemoprevention research in the next millennium will include defining the genotypic and phenotypic (functional and histolog ical) changes during carcinogenesis, the cancer risk conferred by these cha nges, their modulation in preclinical experimentation and randomised clinic al trials by chemopreventive drugs, dietary agents and regimens and treatme nts resulting from early detection. The key elements of this research effor t will be basic and translational risk evaluation programmes; chemopreventi ve and dietary agent drug discovery and development; development of transge nic animal models; required safety and pharmacology studies; well-designed phase I, II and III chemoprevention studies; and much expanded early detect ion programmes. The large number of chemoprevention research programmes now ongoing ensures that the promise of chemoprevention will continue to be re alised in the next decade. (C) 1999 Elsevier Science Ltd. All rights reserv ed.