Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra

Citation
M. Broun et al., Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra, DEVELOPMENT, 126(23), 1999, pp. 5245-5254
Citations number
62
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
DEVELOPMENT
ISSN journal
0950-1991 → ACNP
Volume
126
Issue
23
Year of publication
1999
Pages
5245 - 5254
Database
ISI
SICI code
0950-1991(199912)126:23<5245:CAHOGP>2.0.ZU;2-1
Abstract
We have isolated Cngsc, a hydra homologue of goosecoid gene. The homeodomai n of Cngsc is identical to the vertebrate (65-72%) and Drosophila (70%) ort hologues, When injected into the ventral side of an early Xenopus embryo, C ngsc induces a partial secondary asis. During head formation, Cngsc express ion appears prior to, and directly above, the zone where the tentacles will emerge, but is not observed nearby when the single apical tentacle is form ed, This observation indicates that the expression of the gene is not neces sary for the formation of a tentacle per se. Rather, it may be involved in defining the border between the hypostome and the tentacle zone. When Cngsc (+) tip of an early bud is grafted into the body column, it induces a secon dary asis, while the adjacent Cngsc(-) region has much weaker inductive cap acities. Thus, Cngsc is expressed in a tissue that acts as an organizer, Cn gsc is also expressed in the sensory neurons of the tip of the hupostome an d in the epithelial endodermal cells of the upper part of the body column, The plausible roles of Cngsc in organizer function, head formation and ante rior neuron differentiation are similar to roles goosecoid plays in vertebr ates and Drosophila. It suggests widespread evolutionary conservation of th e function of the gene.