Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides

Citation
Ia. Kozlov et al., Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides, CHEM-EUR J, 6(1), 2000, pp. 151-155
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY-A EUROPEAN JOURNAL
ISSN journal
0947-6539 → ACNP
Volume
6
Issue
1
Year of publication
2000
Pages
151 - 155
Database
ISI
SICI code
0947-6539(200001)6:1<151:NTROAO>2.0.ZU;2-#
Abstract
Altritol nucleic acids (ANAs) are RNA analogues with a phosphorylated D-alt ritol backbone. The nucleobase is attached at the 2-(S)-position of the car bohydrate moiety. We report that ANA oligomers are superior to the correspo nding DNA, RNA, and HNA (hexitol nucleic acid) in supporting efficient none nzymatic template-directed synthesis of complementary RNAs from nucleoside- 5'-phosphoro-2-methyl imidazolides. Activated ANA and HNA monomers do not o ligomerize efficiently on DNA, RNA, HNA, or ANA templates.