Embolization with radiopaque microbeads of polyacrylonitrile hydrogel: Evaluation in swine

Citation
Yp. Gobin et al., Embolization with radiopaque microbeads of polyacrylonitrile hydrogel: Evaluation in swine, RADIOLOGY, 214(1), 2000, pp. 113-119
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
RADIOLOGY
ISSN journal
0033-8419 → ACNP
Volume
214
Issue
1
Year of publication
2000
Pages
113 - 119
Database
ISI
SICI code
0033-8419(200001)214:1<113:EWRMOP>2.0.ZU;2-E
Abstract
PURPOSE: To perform in vitro and in vivo studies of radiopaque microbeads o f polyacrylonitrile (PAN) hydrogel to evaluate their characteristics as emb olic material. MATERIALS AND METHODS: PAN microbeads were analyzed in vitro for swelling i n different concentrations of contrast material and saline solution and inj ected through various microcatheters. In three nonsurvival swine, various o rgans were embolized with PAN microbeads. In eight survival swine, the rete mirabile was embolized with PAN microbeads or polyvinyl alcohol particles. Follow-up angiograms were obtained regularly, and histopathologic analysis was performed at 1 and 6 months. RESULTS: The microbeads were black with a regular shape and smooth surface. They were easily visible in the syringe and easy to inject through the mic rocatheters. When wet, their diameters increased by 40%. The microbeads wer e sufficiently radiopaque to be visible in all vascular territories. Vascul ar occlusion was not permanent, and even when embolization was adequate, so me revascularization was detected at 3 months. The microbeads were intact a nd still radiopaque at 6 months. Histopathologic examination demonstrated v ariable inflammatory reactions and foreign-body giant cell reaction and no angionecrosis or hemorrhage. CONCLUSION: Because PAN microbeads are biocompatible, radiopaque, and easy to handle during embolization procedures, they have potential as a therapeu tic embolic agent.