Antibacterial hydroxycinnamic esters from Piper caninum from Paluma, northQueensland, Australia. The crystal and molecular structure of (+)-bornyl coumarate
Wn. Setzer et al., Antibacterial hydroxycinnamic esters from Piper caninum from Paluma, northQueensland, Australia. The crystal and molecular structure of (+)-bornyl coumarate, PLANTA MED, 65(8), 1999, pp. 747-749
The crude chloroform bark extract of Piper caninum (Piperaceae) exhibits an
tibacterial activity against the Grampositive bacteria, Bacillus cereus, St
aphylococcus aureus, and Streptococcus pneumoniae. The antibacterial agents
in this extract have been isolated using bioactivity-directed chromatograp
hic techniques and identified by NMR spectroscopy as (+)-bornyl p-coumarate
and bornyl caffeate. A single-crystal X-ray structure has been carried out
on (+)-bornyl p-coumarate. The compound crystallizes in the orthorhombic s
pace group P2(1)2(1)2(1) (#19) with a = 12.659(4), b = 13.281(4), and c = 1
0.177(3) Angstrom. Full-matrix least-squares refinement converged at R = 0.
047, and R-w = 0.058.