Antibacterial hydroxycinnamic esters from Piper caninum from Paluma, northQueensland, Australia. The crystal and molecular structure of (+)-bornyl coumarate

Citation
Wn. Setzer et al., Antibacterial hydroxycinnamic esters from Piper caninum from Paluma, northQueensland, Australia. The crystal and molecular structure of (+)-bornyl coumarate, PLANTA MED, 65(8), 1999, pp. 747-749
Citations number
11
Language
INGLESE
art.tipo
Letter
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
0032-0943 → ACNP
Volume
65
Issue
8
Year of publication
1999
Pages
747 - 749
Database
ISI
SICI code
0032-0943(199912)65:8<747:AHEFPC>2.0.ZU;2-J
Abstract
The crude chloroform bark extract of Piper caninum (Piperaceae) exhibits an tibacterial activity against the Grampositive bacteria, Bacillus cereus, St aphylococcus aureus, and Streptococcus pneumoniae. The antibacterial agents in this extract have been isolated using bioactivity-directed chromatograp hic techniques and identified by NMR spectroscopy as (+)-bornyl p-coumarate and bornyl caffeate. A single-crystal X-ray structure has been carried out on (+)-bornyl p-coumarate. The compound crystallizes in the orthorhombic s pace group P2(1)2(1)2(1) (#19) with a = 12.659(4), b = 13.281(4), and c = 1 0.177(3) Angstrom. Full-matrix least-squares refinement converged at R = 0. 047, and R-w = 0.058.