Relation between interleukin-1 beta messenger RNA in gastric fundic mucosaand gastric juice pH in patients infected with Helicobacter pylori

Citation
Mc. Wang et al., Relation between interleukin-1 beta messenger RNA in gastric fundic mucosaand gastric juice pH in patients infected with Helicobacter pylori, J GASTRO, 34, 1999, pp. 10-17
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
JOURNAL OF GASTROENTEROLOGY
ISSN journal
0944-1174 → ACNP
Volume
34
Year of publication
1999
Supplement
11
Pages
10 - 17
Database
ISI
SICI code
0944-1174(199912)34:<10:RBIBMR>2.0.ZU;2-N
Abstract
The effects of Helicobacter pylori infection on gastric acid secretion has not been clarified. The aim of this study was to elucidate the effects of I J. pylori infection on gastric juice pH in relation to gene expression of i nterleukin-1 beta (IL-1 beta), which is reported to inhibit gastric acid se cretion. Gastric juice pH and serum gastrin levels were measured in patient s with peptic ulcer disease. The amount of IL-IB mRNA in gastric fundic gla nd mucosa was also measured by a competitive reverse transcription-polymera se chain reaction method. These parameters were determined before and after treatment with lansoprazole and amoxicillin. Before treatment a significan t positive relation was observed between the amount of IL-1 beta mRNA in ga stric fundic gland mucosa and gastric juice pH, After treatment significant decreases in the amount of IL-1 beta mRNA, gastric juice pH, and serum gas trin levels were observed in patients with eradication of H. pylori, wherea s no significant changes were observed in patients without eradication. The se results suggest that H. pylori infection induces IL-1 beta and suppresse s acid secretion, resulting in increases in gastric juice pH and serum gast rin levels. Eradication of H. pylori decreases IL-1 beta induction, resulti ng in an increase in gastric juice acidity and normalization of serum gastr in levels.