Changing myoepithelial cell distribution during regeneration of rat parotid glands.

Citation
S. Takahashi et al., Changing myoepithelial cell distribution during regeneration of rat parotid glands., INT J EXP P, 80(5), 1999, pp. 283-290
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
ISSN journal
0959-9673 → ACNP
Volume
80
Issue
5
Year of publication
1999
Pages
283 - 290
Database
ISI
SICI code
0959-9673(199910)80:5<283:CMCDDR>2.0.ZU;2-A
Abstract
The distribution of the myoepithelial cells during regeneration of the rat parotid gland after atrophy induced by one week of parotid duct ligation wa s investigated by immunohistochemistry for actin and transmission electron microscopy (TEM). Immunohistochemically, residual ducts were surrounded by actin-positive cells when clips were removed from the duct. Three days late r, most of the newly termed acini originating from the residual ducts were also embraced by actin-positive cells. After 10 days, actin-positivity tend ed to be seen as dots around acini that decreased in number day by day. On day 21 actin-positive cells mainly surrounded intercalated ducts with only a few positive reactions identified at the acinar periphery. Electron micro scopically, residual ducts and newly formed acini were peripherally embrace d by myoepithelial cells before day 5. After day 7, shift of myoepithelial cells from the periphery of acini to the duct-acinar junctional region was identified. Then few myoepithelial cells were identified at the periphery o f acini. These observations indicate that myoepithelial cells migrate from the acinar periphery to the duct-acinar junctional region during rat paroti d regeneration, and that such behaviour is closely related to that seen dur ing rat parotid development.