TiCl4-Mediated Baylis-Hillman and aldol reactions without the direct use of a Lewis base

Citation
Gg. Li et al., TiCl4-Mediated Baylis-Hillman and aldol reactions without the direct use of a Lewis base, TETRAHEDR L, 41(1), 2000, pp. 1-5
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
0040-4039 → ACNP
Volume
41
Issue
1
Year of publication
2000
Pages
1 - 5
Database
ISI
SICI code
0040-4039(20000101)41:1<1:TBAARW>2.0.ZU;2-5
Abstract
TiCl4-Mediated Baylis-Hillman and aldol reactions were developed without th e direct use of a Lewis base. These processes involve the conjugate additio n of TiCl4 to alpha,beta-unsaturated substrates followed by carbonyl coupli ng. Baylis-Hillman olefins were obtained when alpha,beta-unsaturated ketone s were employed as the substrates, whereas beta-halogenated aldol products were generated with an alpha,beta-unsaturated N-acyl benzoxalinone as the M ichael-type acceptor. (C) 1999 Elsevier Science Ltd. All rights reserved.