The Bayesian analysis of a pivotal pharmacokinetic study

Citation
Nj. Rahman et al., The Bayesian analysis of a pivotal pharmacokinetic study, STAT ME M R, 8(3), 1999, pp. 195-216
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Health Care Sciences & Services
Journal title
STATISTICAL METHODS IN MEDICAL RESEARCH
ISSN journal
0962-2802 → ACNP
Volume
8
Issue
3
Year of publication
1999
Pages
195 - 216
Database
ISI
SICI code
0962-2802(199909)8:3<195:TBAOAP>2.0.ZU;2-9
Abstract
The aim of this paper is to carry out a detailed Bayesian population pharma cokinetic analysis of a three-period cross-over study of the drug fluticaso ne propionate carried out in 12 healthy male volunteers. The study was carr ied out to characterize the pharmacokinetics of the drug, in particular to investigate dose proportionality. We examine the appropriateness of modelli ng assumptions via a variety of diagnostic techniques. We also examine the effect of deleting time points at which the concentration was recorded as b elow the limit of quantification, as opposed to including these points as c ensored observations. We assess dose proportionality before carrying out a final combined analysis of data from all three doses.