Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line

Citation
M. Nii et al., Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line, INT J ONCOL, 16(1), 2000, pp. 119-124
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF ONCOLOGY
ISSN journal
1019-6439 → ACNP
Volume
16
Issue
1
Year of publication
2000
Pages
119 - 124
Database
ISI
SICI code
1019-6439(200001)16:1<119:SOMBTI>2.0.ZU;2-Q
Abstract
We have established a highly-metastatic cell line (designated as HNOS) and a non-metastatic cell line (designated as SAT) derived from human oral cavi ty squamous cell carcinoma (SCC). Both lines were transplantable in nude mi ce. The invasive activity through Matrigel-coated membrane of HNOS cells wa s also higher than that of SAT cells, mRNA of TIMP-1 was expressed in SAT c ells but not in HNOS cells. Metastatic and invasive abilities were suppress ed by the overexpression of TIMP-1 in HNOS cells. These results suggest tha t TIMP-1 may have an important role in inhibiting invasion and metastasis o f human oral cavity SCC.