ExoT of cytotoxic Pseudomonas aeruginosa prevents uptake by corneal epithelial cells

Citation
Ba. Cowell et al., ExoT of cytotoxic Pseudomonas aeruginosa prevents uptake by corneal epithelial cells, INFEC IMMUN, 68(1), 2000, pp. 403-406
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
0019-9567 → ACNP
Volume
68
Issue
1
Year of publication
2000
Pages
403 - 406
Database
ISI
SICI code
0019-9567(200001)68:1<403:EOCPAP>2.0.ZU;2-G
Abstract
The presence of invasion-inhibitory activity that is regulated by the trans criptional activator ExsA of cytotoxic Pseudomonas aeruginosa has previousl y been proposed. The results of this study show that both ExoT and ExoS, kn own type III secreted effector proteins of P. aeruginosa that are regulated by ExsA, possess this activity. Invasion was reduced 94.4% by ExoT and 96. 0% by ExoS. Invasion-inhibitory activity is not linked to ADP-ribosylation activity, at least for ExoS, since a noncatalytic mutant also inhibits upta ke by an epithelial cell line (invasion was reduced 96.0% by ExoSE381A).