The preprotein translocase of the outer mitochondrial membrane: receptors and a general import pore

Citation
C. Meisinger et al., The preprotein translocase of the outer mitochondrial membrane: receptors and a general import pore, CELL MOL L, 56(9-10), 1999, pp. 817-824
Citations number
61
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
9-10
Year of publication
1999
Pages
817 - 824
Database
ISI
SICI code
1420-682X(19991130)56:9-10<817:TPTOTO>2.0.ZU;2-2
Abstract
Cytosol-synthesized preproteins destined for the mitochondria are transport ed across the outer membrane by the translocase of the mitochondrial outer membrane (TOM complex). This dynamic transport machinery can be divided int o receptors that recognize preprotein targeting signals and components of t he general import pore complex that mediate preprotein transport across the outer membrane. This review focuses on recent studies dealing with the cen tral questions regarding the pore-forming subunits, and architecture and ga ting of the translocation channel of the outer membrane.