Yeast aging research: recent advances and medical relevance

Authors
Citation
Da. Sinclair, Yeast aging research: recent advances and medical relevance, CELL MOL L, 56(9-10), 1999, pp. 807-816
Citations number
95
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
9-10
Year of publication
1999
Pages
807 - 816
Database
ISI
SICI code
1420-682X(19991130)56:9-10<807:YARRAA>2.0.ZU;2-P
Abstract
The molecular mechanisms of aging are most fully understood for the budding yeast Saccharomyces cerevisiae. Recent advances in our understanding of ag ing in this organism have enabled researchers to answer some fundamental qu estions about the aging process. Is aging due to a multitude of 'mechanisms ' or can there be a key few? Can we design single-gene mutations that will prolong life? Can we prolong life whilst maintaining health and fecundity? The various contributing factors to yeast longevity, uncovered thus far, fa ll into three classes: DNA metabolism, heterochromatin, and metabolic activ ity. However, these separate classes may actually represent different aspec ts of the same aging mechanism based on genome stability. This review exami nes the recent advances in our understanding of yeast aging and discusses t heir relevance, if any, to the human condition.