Genetic basis of methicillin resistance in Staphylococcus aureus

Authors
Citation
B. Berger-bachi, Genetic basis of methicillin resistance in Staphylococcus aureus, CELL MOL L, 56(9-10), 1999, pp. 764-770
Citations number
71
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
9-10
Year of publication
1999
Pages
764 - 770
Database
ISI
SICI code
1420-682X(19991130)56:9-10<764:GBOMRI>2.0.ZU;2-3
Abstract
Methicillin resistance in staphylococci is due to the acquisition of the me cA gene encoding a new penicillin-binding protein (PBP2, PBP2a) that has a lower affinity to methicillin than the endogenous PBPs. PBP2' is involved i n the assembly of the cell wall peptidoglycan in the presence of high conce ntrations of beta-lactarns that otherwise inhibit the endogenous PBPs. The production of PBP2' is under dual control by its own mecR1-mecI- and the pe nicillinase blaR1-bla1-encoded regulatory elements. Resistance to high leve ls of methicillin depends, in addition to PBP2', on chromosomally encoded f actors that are involved in the synthesis and degradation of the peptidogly can. Any mutations that reduce peptidoglycan precursor formation or change the chemical composition of the muropeptide precursor result in lowered res istance.