Antibiotic resistance in microbes

Citation
D. Mazel et J. Davies, Antibiotic resistance in microbes, CELL MOL L, 56(9-10), 1999, pp. 742-754
Citations number
61
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
9-10
Year of publication
1999
Pages
742 - 754
Database
ISI
SICI code
1420-682X(19991130)56:9-10<742:ARIM>2.0.ZU;2-J
Abstract
The treatment of infectious disease is compromised by the development of an tibiotic-resistant strains of microbial pathogens. A variety of biochemical processes are involved that may keep antibiotics out of the cell, alter th e target of the drug, or disable the antibiotic. Studies have shown that re sistance determinants arise by either of two genetic mechanisms: mutation a nd acquisition. Antibiotic resistance genes can be disseminated among bacte rial populations by several processes,but principally by conjugation. Thus the overall problem of antibiotic resistance is one of genetic ecology and a better understanding of the contributing parameters is necessary to devis e rational approaches to reduce the development and spread of antibiotic re sistance and so avoid a critical situation in therapy-a return to a pre-ant ibiotic era.