Evolution of virulence factors in Shiga-toxin-producing Escherichia coli

Authors
Citation
P. Boerlin, Evolution of virulence factors in Shiga-toxin-producing Escherichia coli, CELL MOL L, 56(9-10), 1999, pp. 735-741
Citations number
57
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
9-10
Year of publication
1999
Pages
735 - 741
Database
ISI
SICI code
1420-682X(19991130)56:9-10<735:EOVFIS>2.0.ZU;2-4
Abstract
The major demonstrated or putative virulence factors of Shiga-toxin-produci ng Escherichia coli (STEC) are the Shiga toxins, products of the locus of e nterocyte effacement, and products encoded by the EHEC-hemolysin plasmid. M olecular analysis shows that STEC acquired the majority of these virulence factors by horizontal transfer of genetic material. In the case of Shiga to xins, the phages encoding them are probably responsible for this transfer. For the locus of enterocyte effacement, however, it is not clear how often this transfer took place and which parts of the locus were involved in this transfer. The large EHEC-hemolysin plasmid is clearly a mosaic structure, which arose from multiple recombination events with foreign DNA. Two lineag es of this plasmid can be distinguished, one of which is associated with ch romosomally encoded virulence factors. Despite the wealth of information av ailable, further comparative studies are needed to decipher definitively th e evolution of virulence in STEC.