Short sequence repeats in microbial pathogenesis and evolution

Authors
Citation
A. Van Belkum, Short sequence repeats in microbial pathogenesis and evolution, CELL MOL L, 56(9-10), 1999, pp. 729-734
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
9-10
Year of publication
1999
Pages
729 - 734
Database
ISI
SICI code
1420-682X(19991130)56:9-10<729:SSRIMP>2.0.ZU;2-E
Abstract
Repetitive DNA is ubiquitous in microbial genomes. Different classes of sho rt sequence repeats (SSRs) have been identified and demonstrated to be gene rally heterogeneous in a locus-dependent manner, reflected in variation in the number of repeat units present at a given genomic site or by sequence h eterogeneity among individual units. Both types of variability can be used to assess intra-species genetic diversity. Repeat variability often affects the coding potential of the region in which the repetitive element is loca ted. This implies that determination of the primary structure of variable n umbers of tandem repeats can be used for epidemiological identification pur poses, and also for the analysis of gene function. Precise assessment of SS R structure can also generate insight into the regulation of gene expressio n. Together, DNA repeat analysis in microbial species provides information on both functional and evolutionary aspects of genetic diversity among micr obial isolates.