1,3-Dipolar cycloadditions of exocyclic alpha,beta-unsaturated ketones 1-22
with diazomethane afforded spiro-1-pyrazolines 23-44 in a diastereospecifi
c reaction. The structure and stereochemistry of each compound synthesised
has been elucidated by nmr spectroscopic measurements and other analytical
techniques. It has been proven that the stereochemistry of the starting alp
ha,beta-enones was retained in the course of these cycloadditions.