The ovarian tumor index predicts risk for malignancy

Citation
Dm. Twickler et al., The ovarian tumor index predicts risk for malignancy, CANCER, 86(11), 1999, pp. 2280-2290
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER
ISSN journal
0008-543X → ACNP
Volume
86
Issue
11
Year of publication
1999
Pages
2280 - 2290
Database
ISI
SICI code
0008-543X(199912)86:11<2280:TOTIPR>2.0.ZU;2-W
Abstract
BACKGROUND, Prediction of ovarian malignancy by ultrasonographic findings a nd patient age in the scenario of clinically suspected adnexal masses is a desirable goal. METHODS, Prospective evaluation of clinically suspected adnexal masses was per formed with transvaginal ultrasound using real-time, Doppler velocimetr y, and color-now mapping. Continuous ultrasound variables included ovarian volume, the Sassone morphology scale, and Doppler determination of angle-co rrected systole, diastole, and time-averaged velocity, in addition to patie nt age. The Doppler pulsatility index (PI), Vessel location, presence of a diastolic notch, and echogenic predominance of the lesion, suggestive of de rmoid, also were assessed. RESULTS. Of 244 women with follow-up, 214 had nonmalignant findings (85 of which were benign neoplasms), and 30 had malignant neoplasms. Age and all u ltrasound continuous variables except systole were found to be statisticall y significant (P < 0.05) between patients with both malignant (N = 30) and nonmalignant masses (N = 214), as well as those with benign (N = 85) and ma lignant (N = 30) neoplasms. By adding the continuous measures (age [in year s], ovarian volume [mL], and Sassone morphology scale [1-15]) and weighting other variables ([-10] x PI, central or septal location [+10], peripheral location [-10], and echogenic [-10]), a receiver operating characteristic c urve was generated (area under the curve = 0.91), which was found to be dis criminating, predictive, and able to replicate the more complex logistic re gression model. Prediction of malignancy was generated from the population- based data of the current study. CONCLUSIONS. The Ovarian Tumor Index, which combines patient age with speci fic ultrasonographic markers, is an accurate method for predicting ovarian malignancy in the clinical scenario of suspected adnexal masses. (C) 1999 A merican Cancer Society.