Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a hu
man tumor cell line panel. Harmine (3) showed significant activity against
several cell lines including three drug-resistant KB sublines with various
resistance mechanisms. alpha-(4-Nitrobenzylidine) harmine (16) had a broad
cytotoxicity spectrum (ED50 values from 0.3-1.2 mu g/mL against 1A9, KB, Sa
OS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells). (C) 1999 Published by Else
vier Science Ltd. All rights reserved.