Spontaneous and induced release of prostaglandins, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha by placental tissue from normal andpreeclamptic pregnancies

Citation
I. Munno et al., Spontaneous and induced release of prostaglandins, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha by placental tissue from normal andpreeclamptic pregnancies, AM J REPROD, 42(6), 1999, pp. 369-374
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
42
Issue
6
Year of publication
1999
Pages
369 - 374
Database
ISI
SICI code
1046-7408(199912)42:6<369:SAIROP>2.0.ZU;2-7
Abstract
PROBLEM: The objective of this study was to clarify the role of the main pr oinflammatory cytokines (interleukin [IL]-1: IL-6, tumor necrosis factor [T NF]-alpha) in the pathogenesis of preeclampsia and how these cytokines affe ct one another and the production of prostaglandins (PGs). METHOD OF STUDY: The concentrations of cytokines and PGs in supernatants of placental tissue from preeclamptic and normal women were determined by enz yme-linked immunosorbent assay. RESULTS: The concentrations of the PGs from unstimulated preeclamptic place ntal tissue were significantly higher compared to the concentrations of PGs from normal unstimulated placental tissue. Significant levels of IL-1 beta were observed only in the supernatants of preeclamptic placental tissue. O f interest, an increase in TNF-alpha. production was detected in the supern atants of IL-l-stimulated preeclamptic placental tissue. CONCLUSIONS: The overproduction of TNF-alpha may be related not only to the effect of a stimulant like IL-IP, but mainly to the lack of mechanisms dow n-regulating the production of TNF-alpha.