I. Munno et al., Spontaneous and induced release of prostaglandins, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha by placental tissue from normal andpreeclamptic pregnancies, AM J REPROD, 42(6), 1999, pp. 369-374
PROBLEM: The objective of this study was to clarify the role of the main pr
oinflammatory cytokines (interleukin [IL]-1: IL-6, tumor necrosis factor [T
NF]-alpha) in the pathogenesis of preeclampsia and how these cytokines affe
ct one another and the production of prostaglandins (PGs).
METHOD OF STUDY: The concentrations of cytokines and PGs in supernatants of
placental tissue from preeclamptic and normal women were determined by enz
yme-linked immunosorbent assay.
RESULTS: The concentrations of the PGs from unstimulated preeclamptic place
ntal tissue were significantly higher compared to the concentrations of PGs
from normal unstimulated placental tissue. Significant levels of IL-1 beta
were observed only in the supernatants of preeclamptic placental tissue. O
f interest, an increase in TNF-alpha. production was detected in the supern
atants of IL-l-stimulated preeclamptic placental tissue.
CONCLUSIONS: The overproduction of TNF-alpha may be related not only to the
effect of a stimulant like IL-IP, but mainly to the lack of mechanisms dow
n-regulating the production of TNF-alpha.