Proportion of CD56(+)3(+) T cells in decidual and peripheral lymphocytes of normal pregnancy and spontaneous abortion with and without history of recurrent abortion

Citation
T. Yamamoto et al., Proportion of CD56(+)3(+) T cells in decidual and peripheral lymphocytes of normal pregnancy and spontaneous abortion with and without history of recurrent abortion, AM J REPROD, 42(6), 1999, pp. 355-360
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
42
Issue
6
Year of publication
1999
Pages
355 - 360
Database
ISI
SICI code
1046-7408(199912)42:6<355:POCTCI>2.0.ZU;2-8
Abstract
PROBLEM: The present study investigated the proportion of CD56(+) 3(+) T ce lls in maternal peripheral and decidual lymphocytes in normal pregnancy and spontaneous abortion with and without history of recurrent spontaneous abo rtion (RSA). METHOD OF STUDY: Maternal peripheral blood and decidua were taken from norm al pregnancies and missed abortions with and without RSA. Decidual lymphocy tes were prepared from decidual tissue and analyzed by flow cytometry. RESULTS: In normal pregnancy, the percentages of CD56(+)3(+) T cells in dec idual lymphocytes did not differ from those in the peripheral blood. Howeve r, the proportion of CD56(+) 3(+) T cells in decidual CD3(+) T cells increa sed higher than that in the peripheral CD3(+) T cells. The percentages of d ecidual CD56(+) 3(+) T cells in missed abortions with and without RSA were lower than those in normal pregnancies. CONCLUSION: CD56(+) 3(+) T cells may play a role in the maintenance of preg nancy. The phenomenon, where the proportion of CD56(+) 3(+) T cells in deci dual lymphocytes decreases, may be due to an immunologic event leading to m issed abortion.