DOBUTAMINE INFUSION MODIFIES THERMOREGULATION DURING GENERAL-ANESTHESIA

Citation
T. Shitara et al., DOBUTAMINE INFUSION MODIFIES THERMOREGULATION DURING GENERAL-ANESTHESIA, Anesthesia and analgesia, 83(6), 1996, pp. 1154-1159
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Anesthesiology
Journal title
ISSN journal
0003-2999
Volume
83
Issue
6
Year of publication
1996
Pages
1154 - 1159
Database
ISI
SICI code
0003-2999(1996)83:6<1154:DIMTDG>2.0.ZU;2-P
Abstract
A redistribution of body heat from core to peripheral tissues causes a rapid decrease in core temperature. The present study tested whether a dobutamine infusion would facilitate redistribution and induce a fur ther decrease in core temperature. Volunteers were randomly assigned t o the control group (n = 8) and the experimental group (n = 8). They w ere anesthetized with isoflurane at an end-tidal concentration of near 1.2% for 120 min. In the experimental group, dobutamine was infused a t a rate of 4 mu g . kg(-1) . min(-1). Core temperature, skin temperat ure, tissue temperature, and laser-Doppler perfusion index were measur ed. Leg heat content was calculated by morphometric data and observed temperatures. The decrease in leg heat content was larger in the contr ol group than in the experimental group 30 min after anesthetic induct ion (P < 0.05), In contrast, the core temperature decreased further in the dobutamine group than in the control group 40 min after induction (P < 0.05). Dobutamine induced further hypothermia, presumably by fac ilitating heat transfer and by increasing cutaneous heat loss. Hypothe rmia will be increased when using dobutamine for anesthesia.