Lyso-PAF analogues and lysophosphatidylcholines from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis

Citation
Ba. Shin et al., Lyso-PAF analogues and lysophosphatidylcholines from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis, J NAT PROD, 62(11), 1999, pp. 1554-1557
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
62
Issue
11
Year of publication
1999
Pages
1554 - 1557
Database
ISI
SICI code
0163-3864(199911)62:11<1554:LAALFT>2.0.ZU;2-V
Abstract
A series of phospholipids, including previously undescribed compounds 4-7, were isolated by a bioactivity-guided fractionation from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis in human Liver cells. These compounds were identified as lyso-PAF analogues (1-5) and lys ophosphatidylcholines (6, 7) based on NMR and MS analyses. Compounds 1-7 sp ecifically blocked the conversion of lanosterol into cholesterol in the Cha ng liver cell.