Alcohol and medication interactions

Citation
R. Weathermon et Dw. Crabb, Alcohol and medication interactions, ALCOHOL R H, 23(1), 1999, pp. 40
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public Health & Health Care Science
Journal title
ALCOHOL RESEARCH & HEALTH
ISSN journal
1535-7414 → ACNP
Volume
23
Issue
1
Year of publication
1999
Database
ISI
SICI code
Abstract
Many medications can interact with alcohol, thereby altering the metabolism or effects of alcohol and/or the medication. Some of these interactions ca n occur even at moderate drinking level and result in adverse health effect s for the drinker. Two types of alcohol-medication interactions exist: (1) pharmacokinetic interactions, in which alcohol interferes with the metaboli sm of the medication, and (2) pharmacodynamic interactions, in which alcoho l enhances the effects of the medication, particularly in the central nervo us system (e.g., sedation). Pharmacokinetic interactions generally occur in the liver, where both alcohol and many medications are metabolized frequen tly by the same enzymes. Numerous classes of prescription medications can i nteract with alcohol, including antibiotics, antidepressants, antihistamine s, barbiturates, benzodiazepines, histamine H-2, receptor antagonists, musc le relaxants, nonnarcotic pain medications and anti-inflammatory agents, op ioids, and warfarin. In addition, many over-the-counter and herbal medicati ons can cause negative effects when taken with alcohol.