Man-made mineral fibers induce apoptosis of human peripheral blood mononuclear cells similarly to chrysotile B

Citation
Zj. Ma et al., Man-made mineral fibers induce apoptosis of human peripheral blood mononuclear cells similarly to chrysotile B, INT J MOL M, 4(6), 1999, pp. 633-637
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research General Topics
Journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN journal
1107-3756 → ACNP
Volume
4
Issue
6
Year of publication
1999
Pages
633 - 637
Database
ISI
SICI code
1107-3756(199912)4:6<633:MMFIAO>2.0.ZU;2-M
Abstract
The aim of this study was to investigate whether man-made mineral fibers (M MMF) induce apoptosis of human peripheral blood mononuclear cells (PBMC), a s we recently demonstrated for chrysotile B. In vitro cultivation of PBMC w ith various MMMF as well as chrysotile B clearly produced apoptotic cells. The alteration of the expression for apoptosis related genes at the mRNA le vel during in vitro cultures of PBMC with various MMMF revealed upregulatio n of Flice and Apaf-1 genes and down regulation of TNF receptor 1 and Bid g enes. These results indicate that MMMF induce apoptosis of PBMC in a simila r manner to chrysotile B. However, the process may be mediated not only by the Fas-related apoptotic pathway but also a mitochondrial pathway. Thus, o ne should be aware that respiratory and immunological abnormalities may occ ur in workers who are exposed to MMMFs.