Purpose: We report a case of invasive sphenoid sinus aspergillosis clinical
ly presenting as a pituitary mass.
Methods: After exploration via the trans-sphenoidal approach and subsequent
treatment with amphotericin-B, Ga-67 brain SPECT was performed twice to mo
nitor the therapeutic effect.
Results: Three months after antifungal treatment, Ga-67 brain SPECT showed
partial resolution of the lesion in the sella turcica region. The patient c
ontinued with fluconazole treatment for another 2 months and received anoth
er Ga-67 brain SPECT, which showed complete clearing of the previous lesion
Conclusion: Ga-67 brain SPECT may play a potentially useful role in monitor
ing the therapeutic effect of treatment of invasive sphenoid sinus aspergil