A new diastereoselective synthesis of a 1 beta-methylcarbapenem intermediate

Authors
Citation
Cy. Oh et Wh. Ham, A new diastereoselective synthesis of a 1 beta-methylcarbapenem intermediate, CHEM COMMUN, (23), 1999, pp. 2365-2366
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
1359-7345 → ACNP
Issue
23
Year of publication
1999
Pages
2365 - 2366
Database
ISI
SICI code
1359-7345(1999):23<2365:ANDSOA>2.0.ZU;2-D
Abstract
A 1 beta-methylcarbapenem key intermediate is synthesized from methyl (R)-3 -hydroxybutyrate via the diastereoselective alkylation and regioselective c uprate ring opening of a chiral epoxide which is readily prepared from Shar pless asymmetric epoxidation of the corresponding allylic alcohol.