Three for T: molecular analysis of the low voltage-activated calcium channel family

Authors
Citation
E. Perez-reyes, Three for T: molecular analysis of the low voltage-activated calcium channel family, CELL MOL L, 56(7-8), 1999, pp. 660-669
Citations number
88
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
7-8
Year of publication
1999
Pages
660 - 669
Database
ISI
SICI code
1420-682X(19991115)56:7-8<660:TFTMAO>2.0.ZU;2-0
Abstract
Despite the wealth of information on voltage-gated calcium channels, little is known about low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to selectively block T-type channels has g enerated much interest in their structure, physiology and pharmacology. Thi s review covers the cloning of a new family of calcium channels, their puta tive structure, the electrophysiological evidence that demonstrated that th ese complementary DNAs encoded low voltage-activated, T-type channels, the tissue expression of these genes, and concludes with a discussion of their possible physiological roles.