Vertebrate odorant receptors

Citation
H. Zhao et S. Firestein, Vertebrate odorant receptors, CELL MOL L, 56(7-8), 1999, pp. 647-659
Citations number
95
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
7-8
Year of publication
1999
Pages
647 - 659
Database
ISI
SICI code
1420-682X(19991115)56:7-8<647:VOR>2.0.ZU;2-U
Abstract
Olfactory transduction begins with the binding of an odorous molecule to a protein receptor-odorant receptor-on the cell surface of olfactory neuron. Odorant receptors are encoded by a large gene family belonging to the super family of G-protein-coupled, seven-transmembrane-domain receptors. Since th e identification of the receptor gene family in 1991, a considerable amount of progress has been made in the study of odorant receptors, including asp ects of spatial and temporal expression pattern, the genomic organization o f the receptor genes, regulation of expression, and receptor function. Thes e studies are of critical importance in understanding how the olfactory sys tem recognizes and distinguishes thousands of odors.