Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating

Citation
D. Yamamoto et Y. Nakano, Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating, CELL MOL L, 56(7-8), 1999, pp. 634-646
Citations number
141
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
7-8
Year of publication
1999
Pages
634 - 646
Database
ISI
SICI code
1420-682X(19991115)56:7-8<634:SBMRMA>2.0.ZU;2-3
Abstract
The study of Drosophila melanogaster by a combination of forward genetics w ith specific mutants, and reverse genetics, in which a given gene is expres sed in an appropriate brain area to test its effect on behavior, provides a unique opportunity to explore the causal relationship between a particular gene, its function in the cell and the behavioral outcome at the organismi c level. Enhanced male-to-male courtship has been shown to occur as a resul t of mutations in several different genes. For example, the Voila mutant ex hibits intense GAL4 reporter expression in the tarsal gustatory sensilla, s uggesting the importance of tapping by a male on the female abdomen with hi s forelegs. Feminization of parts of the antennal lobe and mushroom body by targeted expression of a female-determining gene transformer(+) (tra(+)) d rives the male to court other males. Mutations in the tra target gene fruit less (fru), which is expressed in the antennal lobe as well as the suboesop hageal ganglion (the gustatory inputs are processed here), also induce homo sexual courtship in males. These results suggest that sensory inputs mediat ed and/or processed by the tarsal receptors, suboesophageal ganglion, anten nal lobe and mushroom body contribute to the regulation of male-female cour tship. Mosaic analysis localized the neural center for male courtship behav ior to the posterior dorsal brain, in which the sensory information process ed by the aforementioned neural structures may be integrated. Another mosai c study mapped the neural center for female sexual behavior, as measured by her receptiveness to copulation, to the anterior dorsal brain. The issue a s to how the mutations that reduce female sexual receptiveness, e.g. dissat isfaction (dsf), spinster (spin) and chaste (cht), affect the structure and /or function of this neural center deserves to be addressed urgently.