Nickel-binding proteins

Citation
Rk. Watt et Pw. Ludden, Nickel-binding proteins, CELL MOL L, 56(7-8), 1999, pp. 604-625
Citations number
195
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
7-8
Year of publication
1999
Pages
604 - 625
Database
ISI
SICI code
1420-682X(19991115)56:7-8<604:NP>2.0.ZU;2-J
Abstract
Nickel enzymes are a relatively new class of metalloenzymes. The seven know n nickel enzymes are urease, hydrogenase, CO-dehydrogenase, methyl-coenzyme M reductase, Ni-superoxide dismutase, glyoxalase I and cis-trans isomerase . The requirement for nickel implies the presence of a nickel-processing sy stem, since free transition metals are harmful to the cell. A nickel-proces sing system involves the recognition and transport of nickel into the cell and the handling of the nickel once it enters the cell until it is inserted into the nickel enzyme. Several mechanisms for nickel transport have been identified and will be reviewed here. Accessory proteins required for the b iosynthesis of the nickel active site have been identified. Accessory prote ins bind the nickel when it enters the cell and are proposed to assist with the insertion of nickel into the enzyme. The function of the characterized nickel-processing proteins is described, and models for nickel insertion i nto the nickel enzymes are presented.