Nitric oxide and cellular respiration

Citation
M. Brunori et al., Nitric oxide and cellular respiration, CELL MOL L, 56(7-8), 1999, pp. 549-557
Citations number
57
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
56
Issue
7-8
Year of publication
1999
Pages
549 - 557
Database
ISI
SICI code
1420-682X(19991115)56:7-8<549:NOACR>2.0.ZU;2-9
Abstract
The role of nitric oxide (NO) as a signalling molecule involved in many pat hophysiological processes (e.g., smooth muscle relaxation, inflammation, ne urotransmission, apoptosis) has been elaborated during the last decade. Sin ce NO has also been found to inhibit cellular respiration, we review here t he available information on the interactions of NO with cytochrome c oxidas e (COX), the terminal enzyme of the respiratory chain. The effect of NO on cellular respiration is first summarized to present essential evidence for the fact that NO is a potent reversible inhibitor of in vivo O-2 consumptio n. This information is then correlated with available experimental evidence on the reactions of NO with purified COX. Finally, since COX has been prop osed to catalyze the degradation of NO into either nitrous oxide (N2O) or n itrite, we consider the putative role of this enzyme in the catabolism of N O in vivo.