A comparative study of Embelia schiperi and Embelia keniensis on blood glucose and triglycerides in normal and epinephrine-induced hyperglycemic mice

Citation
A. Kato et al., A comparative study of Embelia schiperi and Embelia keniensis on blood glucose and triglycerides in normal and epinephrine-induced hyperglycemic mice, AM J CHIN M, 27(3-4), 1999, pp. 365-370
Citations number
4
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
AMERICAN JOURNAL OF CHINESE MEDICINE
ISSN journal
0192-415X → ACNP
Volume
27
Issue
3-4
Year of publication
1999
Pages
365 - 370
Database
ISI
SICI code
0192-415X(1999)27:3-4<365:ACSOES>2.0.ZU;2-5
Abstract
Intraperitoneal administration of the methanol extract of Embelia schiperi (ES) to normal mice caused a significant decrease in blood glucose (p<0.01) and a significant increase in triglycerides 4 hours after administration a t 100 mg/kg (p<0.01). The toluene fraction of Embelia keniensis methanol ex tract (TS) showed hypoglycemic and lipid lowering activity 7 hours after in traperitoneal administration at 100 mg/kg. In addition, TS (100 mg/kg) admi nistration significantly decreased blood glucose in epinephrine-induced hyp erglycemic mice (p<0.01). Moreover, ES tended to increase while TS tended t o decrease the blood triglycerides in epinephrine-induced hyperglycemic mic e. On the other hand, no changes in blood cholesterol were observed after t he administration of ES or TS in normal and epinephrine-induced hyperglycem ic mice. We found that two species from Embelia, ES and TS, have different activities on blood glucose and triglycerides in normal and epinephrine-ind uced hyperglycemic mice.