THE CHANGES OF SERUM-SOLUBLE HLA-CLASS-I AND CD8 CONCENTRATIONS DURING INTERFERON TREATMENT OF CHRONIC HEPATITIS-C PATIENTS

Citation
M. Hagihara et al., THE CHANGES OF SERUM-SOLUBLE HLA-CLASS-I AND CD8 CONCENTRATIONS DURING INTERFERON TREATMENT OF CHRONIC HEPATITIS-C PATIENTS, HEPATOLOGY RESEARCH, 6(6), 1997, pp. 316-323
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
1386-6346
Volume
6
Issue
6
Year of publication
1997
Pages
316 - 323
Database
ISI
SICI code
1386-6346(1997)6:6<316:TCOSHA>2.0.ZU;2-F
Abstract
wSerum soluble HLA-class I and CD8 molecules were sequentially (pre, d uring, and post-therapy) measured by sandwich ELISA, in 20 interferon (IFN)-treated chronic hepatitis C (CHC) patients, who were judged as r esponders (n = 8) or non-responders (n = 12) with respect to the respo nse to the therapy. Pretreatment levels of sHLA-I and sCD8 did not dif fer between responders and non-responders. Both values increased just after the start of therapy and peaked al 2-4 weeks. The IFN was discon tinued at 24 weeks, when sHLA-I decreased to baseline levels in respon ders, whereas they remained at levels significantly higher than baseli ne levels even at 48 weeks in non-responders (P < 0.01). sCD8 decrease d significantly under than baseline levels at 48 weeks in responders ( P < 0.01), in contrast in non-responders, sCD8 did not decrease beyond baseline levels. In summary, serum levels of sHLA-I and sCD8 were ele vated by the IFN treatment, and serial follow-up of these immunologica l parameters could provide additive information regarding the response to IFN therapy. (C) 1997 Elsevier Science Ireland Ltd.