Can androgen therapy replete lean body mass and improve muscle function inwasting associated with human immunodeficiency virus infection?

Citation
S. Bhasin et M. Javanbakht, Can androgen therapy replete lean body mass and improve muscle function inwasting associated with human immunodeficiency virus infection?, J PARENT EN, 23(6), 1999, pp. S195-S201
Citations number
82
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrynology, Metabolism & Nutrition
Journal title
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
ISSN journal
0148-6071 → ACNP
Volume
23
Issue
6
Year of publication
1999
Supplement
S
Pages
S195 - S201
Database
ISI
SICI code
0148-6071(199911/12)23:6<S195:CATRLB>2.0.ZU;2-C
Abstract
A significant number of men who are infected with the human immunodeficienc y virus (HIV) have low testosterone levels. Androgen deficiency in HIV-infe cted patients is associated with decreased muscle mass and function, and ad verse disease outcome. Administration of replacement doses of testosterone to healthy hypogonadal men augments lean body mass, muscle size, and maxima l voluntary strength. Recent studies have shown that physiologic testostero ne replacement in HIV-infected men with weight loss who have low testostero ne levels can also increase muscle mass and effort-dependent strength. Howe ver, further studies are needed to determine whether androgen therapy can i mprove physical function and health-related outcomes in HIV-infected men.