Comparison of proton therapy and conformal X-ray therapy in non-small celllung cancer (NSCLC)

Citation
Chm. Lee et al., Comparison of proton therapy and conformal X-ray therapy in non-small celllung cancer (NSCLC), BR J RADIOL, 72(863), 1999, pp. 1078-1084
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
BRITISH JOURNAL OF RADIOLOGY
ISSN journal
0007-1285 → ACNP
Volume
72
Issue
863
Year of publication
1999
Pages
1078 - 1084
Database
ISI
SICI code
Abstract
This study compares the performance of one proton and four conformal X-ray planning techniques In treating non-small cell lung cancer (NSCLC). The tre atment volumes for 13 NSCLC patients undergoing radical radiotherapy were p lanned using the five different techniques and dose-volume histograms (DVH) were used extensively in the comparative analysis. The minimum dose to the phase 2 target volume was escalated to 90 Gy, or until the point at which pre-set tolerance limits of spinal cord or lung were exceeded. The proton p lan could treat nine of the 13 patients up to a dose of 90 Gy. Among the fo ur X-ray techniques, performance varied enormously. One of them could not t reat any of the patients, even to the conventional 60 Gy level, without fai ling to meet one or more of the criteria, whilst another one could treat 10 out of the 13 patients, although with this technique only four were permit ted to have the dose escalated to 90 Gy. It. was also found that two of the 13 patients could not be treated by any of the proton or X-ray plans to th e conventional level, and were therefore considered unsuitable for radical radiotherapy. Various issues in conformal NSCLC radiotherapy including orga n movement, tumour control, other possible organs at risk etc., are also di scussed.